Les publications les plus récentes
Bachelot A, Bouvier A, Riou J, Thepot S, Giltat A, Nunes Gomes C, Paillassa J, Jouanneau-Courville R, Renard M, Beucher A, Cottin L, Wiber M, Ribourtout B, Geneviève F, Luque Paz D, Tanguy-Schmidt A, Ugo V, Hunault-Berger M, Blanchet O, Orvain C. Relationship between comorbidities, mutational profile, and outcome after intensive chemotherapy in patients older than 60 years with acute myeloid leukemia: Assessment of different risk scores. Am J Hematol. 2023 Jun;98(6):922-931. doi: 10.1002/ajh.26917.
Desprez, C., Kouatchet, A., Marchand, T., Mear, J. B., Tadié, J. M., Peterlin, P., Chevalier, P., Canet, E., Couturier, M.-A., Guillerm, G., Bodenes, L., Gyan, E., Villate, A., Ehrmann, S., Lebreton, A., Lester, M.-A., Fronteau, C., Larhantec, G., André, V., … Orvain, C. (2023). Outcome of patients with newly diagnosed AML admitted to the ICU, including preemptive admission – a multi-center study. Annals of Hematology. https://doi.org/10.1007/s00277-023-05205-6
PRODUCTION SCIENTIFIQUE
_______________________________________________2023_______________________________________________
Bachelot A, Bouvier A, Riou J, Thepot S, Giltat A, Nunes Gomes C, Paillassa J, Jouanneau-Courville R, Renard M, Beucher A, Cottin L, Wiber M, Ribourtout B, Geneviève F, Luque Paz D, Tanguy-Schmidt A, Ugo V, Hunault-Berger M, Blanchet O, Orvain C. Relationship between comorbidities, mutational profile, and outcome after intensive chemotherapy in patients older than 60 years with acute myeloid leukemia: Assessment of different risk scores. Am J Hematol. 2023 Jun;98(6):922-931. doi: 10.1002/ajh.26917.
Chabrun F, Lacombe V, Dieu X, Geneviève F, Urbanski G. Accurate stratification between VEXAS syndrome and differential diagnoses by deep learning analysis of peripheral blood smears. Clin Chem Lab Med. 2023 Feb 2. doi: 10.1515/cclm-2022-1283.
Declerck C, Giltat A, Boutemy R, Brisset-Dheilly M, Pelhatre A, Hunault-Berger M, Kempf M, Kouatchet A, Mahieu R, Tanguy-Schmidt A, Orvain C. Implementation of a new blood cultures sampling strategy in patients receiving intensive chemotherapy for acute leukemia and/or hematopoietic cell transplantation. Leuk Lymphoma. 2023 Jun;64(6):1204-1207. doi: 10.1080/10428194.2023.2196595.
Desprez C, Kouatchet A, Marchand T, Mear JB, Tadié JM, Peterlin P, Chevalier P, Canet E, Couturier MA, Guillerm G, Bodenes L, Gyan E, Villate A, Ehrmann S, Lebreton A, Lester MA, Fronteau C, Larhantec G, André V, Riou J, Hunault-Berger M, Schmidt-Tanguy A, Orvain C. Outcome of patients with newly diagnosed AML admitted to the ICU, including preemptive admission - a multi-center study. Ann Hematol. 2023 Jun;102(6):1383-1393. doi: 10.1007/s00277-023-05205-6.
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Desprez, C., Riou, J., Peterlin, P., Marchand, T., Couturier, M.-A., Villate, A., Mear, J.-B., Chevalier, P., Guillerm, G., Gyan, E., Schmidt-Tanguy, A., Walter, R.B., Hunault-Berger, M., Orvain, C., 2022. Comparison of scoring systems evaluating suitability for intensive chemotherapy in adults with acute myeloid leukemia—a Grand Ouest Against Leukemia (GOAL) study. Leukemia 36, 2408–2417. https://doi.org/10.1038/s41375-022-01677-z
Drevin, G., Briet, M., Bazzoli, C., Gyan, E., Schmidt, A., Dombret, H., Orvain, C., Giltat, A., Recher, C., Ifrah, N., Guardiola, P., Hunault-Berger, M., Abbara, C., 2022. Daunorubicin and Its Active Metabolite Pharmacokinetic Profiles in Acute Myeloid Leukaemia Patients: A Pharmacokinetic Ancillary Study of the BIG-1 Trial. Pharmaceutics 14, 792. https://doi.org/10.3390/pharmaceutics14040792
Dulucq, S., Nicolini, F.E., Rea, D., Cony-Makhoul, P., Charbonnier, A., Escoffre-Barbe, M., Coiteux, V., Lenain, P., Rigal-Huguet, F., Liu, J., Guerci-Bresler, A., Legros, L., Ianotto, J.-C., Gardembas, M., Turlure, P., Dubruille, V., Rousselot, P., Martiniuc, J., Jardel, H., Johnson-Ansah, H., Joly, B., Henni, T., Cayssials, E., Zunic, P., Berger, M.G., Villemagne, B., Robbesyn, F., Morisset, S., Mahon, F.-X., Etienne, G., 2022. Kinetics of early and late molecular recurrences after first-line imatinib cessation in chronic myeloid leukemia: updated results from the STIM2 trial. haematol 107, 2859–2869. https://doi.org/10.3324/haematol.2022.280811
Gyan, E., Pigneux, A., Hunault, M., Peterlin, P., Carré, M., Bay, J.-O., Bonmati, C., Gallego-Hernanz, M.-P., Lioure, B., Bertrand, P., Vallet, N., Ternant, D., Darrouzain, F., Picou, F., Béné, M.-C., Récher, C., Hérault, O., 2022. Adjunction of a fish oil emulsion to cytarabine and daunorubicin induction chemotherapy in high-risk AML. Sci Rep 12, 9748. https://doi.org/10.1038/s41598-022-13626-y
Lacombe, V., Beucher, A., Urbanski, G., Le Corre, Y., Cottin, L., Croué, A., Bouvier, A., 2022. Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome. Exp Hematol Oncol 11, 6. https://doi.org/10.1186/s40164-022-00262-5
Lemoine, S., Mornet, C., Quintin-Roue, I., Rousselet, M.-C., Cottin, L., Georgeais, A., Dubouis, L., Boyer, F., Orvain, C., Caillon, C., Renard, M., Le Brun, V., Le Clech, L., Ianotto, J.-C., Génin, E., Burroni, B., Ugo, V., Paz, D.L., Lippert, E., 2022. Histological and genetic characterization and follow-up of 130 patients with chronic triple-negative thrombocytosis. haematol 107, 2725–2731. https://doi.org/10.3324/haematol.2022.280917
Roux, B., Picou, F., Debeissat, C., Koubi, M., Gallay, N., Hirsch, P., Ravalet, N., Béné, M.C., Maigre, M., Hunault, M., Mosser, J., Etcheverry, A., Gyan, E., Delhommeau, F., Domenech, J., Herault, O., 2022. Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia. Cancer Gene Ther 29, 1263–1275. https://doi.org/10.1038/s41417-022-00441-w
Sureau, L., Buors, C., Ianotto, J.-C., Boyer, F., Tanguy-Schmidt, A., Roy, L., Cayssials, E., Cailly, L., Chomel, J.-C., Chauveau, A., Orvain, C., Mansier, O., Ranta, D., Robles, M., Gyan, E., Hérault, O., Nimubona, S., Marchand, T., Lippert, E., Riou, J., Ugo, V., Luque Paz, D., 2022. JAK2 V617F polycythemia vera and essential thrombocythemia: dynamic clinical features associated with long-term outcomes. Blood Cancer J. 12, 56. https://doi.org/10.1038/s41408-022-00646-0
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Baroud, M., Lepeltier, E., Thepot, S., El-Makhour, Y., Duval, O., 2021. The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery. Nanoscale Adv. 3, 2157–2179. https://doi.org/10.1039/D0NA01084G
Couturier, M.-A., Thomas, X., Raffoux, E., Huguet, F., Berthon, C., Simand, C., Gallego-Hernanz, M.-P., Hicheri, Y., Hunault Berger, M., Saillard, C., Leguay, T., Loiseau, C., Béné, M.-C., Chevallier, P., 2021. Blinatumomab + ponatinib for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia in adults. Leuk Lymphoma 62, 620–629. https://doi.org/10.1080/10428194.2020.1844198
Foucault, A., Vallet, N., Ravalet, N., Picou, F., Bene, M.C., Gyan, E., Herault, O., 2021. Occupational pesticide exposure increases risk of acute myeloid leukemia: a meta-analysis of case–control studies including 3,955 cases and 9,948 controls. Sci Rep 11, 2007. https://doi.org/10.1038/s41598-021-81604-x
Foucault, A., Ravalet, N., Besombes, J., Picou, F., Gallay, N., Babin, L., Bourgeais, J., Hamard, S., Domenech, J., Loyer, P., Vallet, N., Lejeune, J., Gyan, E., Béné, M.C., Vallette, F., Olivier, C., Hérault, O., 2021. Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition. Cancers 13, 5699. https://doi.org/10.3390/cancers13225699
Lacombe, V., Prevost, M., Bouvier, A., Thépot, S., Chabrun, F., Kosmider, O., Lacout, C., Beucher, A., Lavigne, C., Geneviève, F., Urbanski, G., 2021. Vacuoles in neutrophil precursors in VEXAS syndrome: diagnostic performances and threshold. Br J Haematol 195, 286–289. https://doi.org/10.1111/bjh.17679
Lacombe, V., Nunes Gomes, C., Robin, J., Thépot, S., François, S., Cottin, L., Ugo, V., Dieu, X., Abgueguen, P., Daniel, V., Giltat, A., Hunault, M., Riou, J., Orvain, C., Schmidt, A., 2021. Risk of infection according to the gamma globulin level in the 100 days following allogeneic stem cell transplantations. Eur J Haematol 107, 489–496. https://doi.org/10.1111/ejh.13686
Lemoine, S., Renard, M., Bouvier, A., Orvain, C., Giltat, A., Cottin, L., Blanchet, O., Hunault-Berger, M., Ugo, V., Luque Paz, D., 2021. No detection of atypical one-base deletion of CALR exon 9 with fragment analysis: A molecular trap to avoid. Blood Cells, Molecules, and Diseases 90, 102589. https://doi.org/10.1016/j.bcmd.2021.102589
Luque Paz, D., Cottin, L., Lippert, E., Robin, J.-B., Bescond, C., Genevieve, F., Boyer, F., Quintin-Roue, I., Rousselet, M.-C., Burroni, B., Hunault-Berger, M., Ugo, V., Ianotto, J.-C., Orvain, C., 2021. Different number of circulating CD34 + cells in essential thrombocythemia, prefibrotic/early primary myelofibrosis, and overt primary myelofibrosis. Ann Hematol. https://doi.org/10.1007/s00277-021-04672-z
Peterlin, P., Gaschet, J., Guillaume, T., Garnier, A., Eveillard, M., Le Bourgeois, A., Cherel, M., Debord, C., Le Bris, Y., Theisen, O., Godon, C., Mahé, B., Dubruille, V., Wuilleme, S., Touzeau, C., Gastinne, T., Blin, N., Lok, A., Tessoulin, B., Le Gouill, S., Moreau, P., Béné, M.-C., Chevallier, P., 2021. A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Med 10, 642–648. https://doi.org/10.1002/cam4.3648
Ravalet, N., Foucault, A., Picou, F., Gombert, M., Renoult, E., Lejeune, J., Vallet, N., Lachot, S., Rault, E., Gyan, E., Bene, M.C., Herault, O., 2021. Automated Early Detection of Myelodysplastic Syndrome within the General Population Using the Research Parameters of Beckman-Coulter DxH 800 Hematology Analyzer. Cancers (Basel) 13. https://doi.org/10.3390/cancers13030389
Sureau, L., Orvain, C., Ianotto, J.-C., Ugo, V., Kiladjian, J.-J., Luque Paz, D., Riou, J., 2021. Efficacy and tolerability of Janus kinase inhibitors in myelofibrosis: a systematic review and network meta-analysis. Blood Cancer J. 11, 135. https://doi.org/10.1038/s41408-021-00526-z
Tondeur, S., Paul, F., Riou, J., Mansier, O., Ranta, D., Le Clech, L., Lippert, E., Tavitian, S., Chaoui, D., Mercier, M., De Renzis, B., Cottin, L., Cassinat, B., Chrétien, J.-M., Ianotto, J.-C., Allangba, O., Marzac, C., Voillat, L., Boyer, F., Orvain, C., Hunault-Berger, M., Girodon, F., Kiladjian, J.-J., Ugo, V., Luque Paz, D., 2021. Long-term follow-up of JAK2 exon 12 polycythemia vera: a French Intergroup of Myeloproliferative Neoplasms (FIM) study. Leukemia 35, 871–875. https://doi.org/10.1038/s41375-020-0991-x
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Baccini, V., Geneviève, F., Jacqmin, H., Chatelain, B., Girard, S., Wuilleme, S., Vedrenne, A., Guiheneuf, E., Toussaint-Hacquard, M., Everaere, F., Soulard, M., Lesesve, J.-F., Bardet, V., 2020. Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC). JCM 9, 808. https://doi.org/10.3390/jcm9030808
Bouvier, A., Riou, J., Thépot, S., Sutra Del Galy, A., François, S., Schmidt, A., Orvain, C., Estienne, M.-H., Villate, A., Luque Paz, D., Cottin, L., Ribourtout, B., Beucher, A., Delneste, Y., Ifrah, N., Ugo, V., Hunault-Berger, M., Blanchet, O., 2020. Quantitative chimerism in CD3-negative mononuclear cells predicts prognosis in acute myeloid leukemia patients after hematopoietic stem cell transplantation. Leukemia 34, 1342–1353. https://doi.org/10.1038/s41375-019-0624-4
Cottin, L., Riou, J., Orvain, C., Ianotto, J.C., Boyer, F., Renard, M., Truchan‐Graczyk, M., Murati, A., Jouanneau‐Courville, R., Allangba, O., Mansier, O., Burroni, B., Rousselet, M.-C., Quintin‐Roué, I., Martin, A., Sadot‐Lebouvier, S., Delneste, Y., Chrétien, J., Hunault‐Berger, M., Blanchet, O., Lippert, E., Ugo, V., Luque Paz, D., 2020. Sequential mutational evaluation of CALR ‐mutated myeloproliferative neoplasms with thrombocytosis reveals an association between CALR allele burden evolution and disease progression. Br J Haematol 188, 935–944. https://doi.org/10.1111/bjh.16276
El-Khoury, M., Cabagnols, X., Mosca, M., Vertenoeil, G., Marzac, C., Favale, F., Bluteau, O., Lorre, F., Tisserand, A., Rabadan Moraes, G., Ugo, V., Ianotto, J.-C., Rey, J., Solary, E., Roy, L., Rameau, P., Debili, N., Pasquier, F., Casadevall, N., Marty, C., Constantinescu, S.N., Raslova, H., Vainchenker, W., Plo, I., 2020. Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms. Oncogene 39, 5323–5337. https://doi.org/10.1038/s41388-020-1368-3
Feriel, J., Depasse, F., Geneviève, F., 2020. How I investigate basophilia in daily practice. Int J Lab Hem 42, 237–245. https://doi.org/10.1111/ijlh.13146
Kouzi, F., Zibara, K., Bourgeais, J., Picou, F., Gallay, N., Brossaud, J., Dakik, H., Roux, B., Hamard, S., Le Nail, L.-R., Hleihel, R., Foucault, A., Ravalet, N., Rouleux-Bonnin, F., Gouilleux, F., Mazurier, F., Bene, M.C., Akl, H., Gyan, E., Domenech, J., El-Sabban, M., Herault, O., 2020. Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells. Oncogene 39, 1198–1212. https://doi.org/10.1038/s41388-019-1069-y
Paillassa, J., Cornet, E., Noel, S., Tomowiak, C., Lepretre, S., Vaudaux, S., Dupuis, J., Devidas, A., Joly, B., Petitdidier-Lionnet, C., Haiat, S., Mariette, C., Thieblemont, C., Decaudin, D., Validire-Charpy, P., Drenou, B., Eisenmann, J.-C., Uribe, M.O., Olivrie, A., Touati, M., Lambotte, O., Hermine, O., Karsenti, J.-M., Feugier, P., Vaillant, W., Gutnecht, J., Lippert, E., Huysman, F., Ghomari, K., Boubaya, M., Levy, V., Riou, J., Damaj, G., Tanguy-Schmidt, A., Hunault-Berger, M., Troussard, X., 2020. Analysis of a cohort of 279 patients with hairy-cell leukemia (HCL): 10 years of follow-up. Blood Cancer J. 10, 62. https://doi.org/10.1038/s41408-020-0328-z
Luque Paz, D., Jouanneau-Courville, R., Riou, J., Ianotto, J.-C., Boyer, F., Chauveau, A., Renard, M., Chomel, J.-C., Cayssials, E., Gallego-Hernanz, M.-P., Pastoret, C., Murati, A., Courtier, F., Rousselet, M.-C., Quintin-Roué, I., Cottin, L., Orvain, C., Thépot, S., Chrétien, J.-M., Delneste, Y., Ifrah, N., Blanchet, O., Hunault-Berger, M., Lippert, E., Ugo, V., 2020. Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation. Blood Advances 4, 4887–4897. https://doi.org/10.1182/bloodadvances.2020002271
Orvain, C., Balsat, M., Tavernier, E., Marolleau, J.-P., Pabst, T., Chevallier, P., de Gunzburg, N., Cacheux, V., Rigal-Huguet, F., Chantepie, S., Caillot, D., Chalandon, Y., Frayfer, J., Bonmati, C., Lheritier, V., Ifrah, N., Dombret, H., Boissel, N., Hunault-Berger, M., 2020. Thromboembolism Prophylaxis in Adult Patients with Acute Lymphoblastic Leukemia Treated in the GRAALL-2005 Study. Blood blood.2020004919. https://doi.org/10.1182/blood.2020004919
Vantyghem, S., Peterlin, P., Thépot, S., Ménard, A., Dubruille, V., Debord, C., Guillaume, T., Garnier, A., Le Bourgeois, A., Wuilleme, S., Godon, C., Theisen, O., Eveillard, M., Delaunay, J., Maisonneuve, H., Morineau, N., Villemagne, B., Vigouroux, S., Subiger, F., Lestang, E., Loirat, M., Parcelier, A., Godmer, P., Mercier, M., Trebouet, A., Luque Paz, D., Le Calloch, R., Le Clech, L., Bossard, C., Moreau, A., Ugo, V., Hunault, M., Moreau, P., Le Gouill, S., Chevallier, P., Béné, M.C., Le Bris, Y., 2020. Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. Haematologica haematol.2019.242677. https://doi.org/10.3324/haematol.2019.242677
_______________________________________________2019 ________________________________________________
Beucher, A., Dib, M., Orvain, C., Bouvier, A., Jouanneau‐Courville, R., Dobo, I., Cottin, L., Guardiola, P., Rousselet, M., Blanchet, O., Hunault, M., Ugo, V., Luque Paz, D., 2019. Next generation sequencing redefines a triple negative essential thrombocythaemia as double‐positive with rare mutations on JAK 2 V617 and MPL W515 hotspots. Br J Haematol 186, 785–788. https://doi.org/10.1111/bjh.15954
Bondu, S., Alary, A.-S., Lefèvre, C., Houy, A., Jung, G., Lefebvre, T., Rombaut, D., Boussaid, I., Bousta, A., Guillonneau, F., Perrier, P., Alsafadi, S., Wassef, M., Margueron, R., Rousseau, A., Droin, N., Cagnard, N., Kaltenbach, S., Winter, S., Kubasch, A.-S., Bouscary, D., Santini, V., Toma, A., Hunault, M., Stamatoullas, A., Gyan, E., Cluzeau, T., Platzbecker, U., Adès, L., Puy, H., Stern, M.-H., Karim, Z., Mayeux, P., Nemeth, E., Park, S., Ganz, T., Kautz, L., Kosmider, O., Fontenay, M., 2019. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome. Sci Transl Med 11. https://doi.org/10.1126/scitranslmed.aav5467
Cottin, L., Riou, J., Boyer, F., Bouvier, A., Zannetti, A., Blouet, A., Truchan-Graczyk, M., Jouanneau-Courville, R., Beucher, A., Ribourtout, B., Orvain, C., Hunault-Berger, M., Blanchet, O., Ugo, V., Luque Paz, D., 2019. WT1 gene is overexpressed in myeloproliferative neoplasms, especially in myelofibrosis. Blood Cells, Molecules, and Diseases 75, 35–40. https://doi.org/10.1016/j.bcmd.2018.12.004
Guénot, C., Lacombe, F., Allou, K., Dumezy, F., Feuillard, J., Geneviève, F., Guérin, E., Guy, J., Maynadié, M., Ballon, O.W., Preudhomme, C., Baruchel, A., Dombret, H., Ifrah, N., Béné, M.C., Groupe d’Etude Immunologique des Leucémies (GEIL), 2019. Peripheral blood minimal/measurable residual disease assessed in flow cytometry in acute myeloblastic leukemia. Leukemia 33, 1814–1816. https://doi.org/10.1038/s41375-019-0393-0
Leveque, X., Hochane, M., Geraldo, F., Dumont, S., Gratas, C., Oliver, L., Gaignier, C., Trichet, V., Layrolle, P., Heymann, D., Herault, O., Vallette, F.M., Olivier, C., 2019. Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro. Stem Cells 37, 1083–1094. https://doi.org/10.1002/stem.3014
Luque Paz, D., Mansier, O., Riou, J., Conejero, C., Roy, L., Belkhodja, C., Ugo, V., Giraudier, S., 2019. Positive impact of molecular analysis on prognostic scores in essential thrombocythemia: a single center prospective cohort experience. Haematologica 104, e134–e137. https://doi.org/10.3324/haematol.2018.197699
Mheidly, K., Lamy De La Chapelle, T., Hunault, M., Benboubker, L., Benchalal, M., Moreau, P., Baugier de Materre, A., Decaux, O., Laribi, K., 2019. New insights in the treatment of patients with solitary bone plasmacytoma. Leuk Lymphoma 60, 2810–2813. https://doi.org/10.1080/10428194.2019.1605067
Picou, F., Vignon, C., Debeissat, C., Lachot, S., Kosmider, O., Gallay, N., Foucault, A., Estienne, M.-H., Ravalet, N., Bene, M.C., Domenech, J., Gyan, E., Fontenay, M., Herault, O., 2019. Bone marrow oxidative stress and specific antioxidant signatures in myelodysplastic syndromes. Blood Adv 3, 4271–4279. https://doi.org/10.1182/bloodadvances.2019000677
Sébert, M., Renneville, A., Bally, C., Peterlin, P., Beyne-Rauzy, O., Legros, L., Gourin, M.-P., Sanhes, L., Wattel, E., Gyan, E., Park, S., Stamatoullas, A., Banos, A., Laribi, K., Jueliger, S., Bevan, L., Chermat, F., Sapena, R., Nibourel, O., Chaffaut, C., Chevret, S., Preudhomme, C., Adès, L., Fenaux, P., 2019. A phase II study of guadecitabine in higher-risk myelodysplastic syndrome and low blast count acute myeloid leukemia after azacitidine failure. Haematologica 104, 1565–1571. https://doi.org/10.3324/haematol.2018.207118
Tanasi, I., Ba, I., Sirvent, N., Braun, T., Cuccuini, W., Ballerini, P., Duployez, N., Tanguy-Schmidt, A., Tamburini, J., Maury, S., Doré, E., Himberlin, C., Duclos, C., Chevallier, P., Rousselot, P., Bonifacio, M., Cavé, H., Baruchel, A., Dombret, H., Soulier, J., Landman-Parker, J., Boissel, N., Clappier, E., 2019. Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements. Blood 134, 1351–1355. https://doi.org/10.1182/blood.2019001244
_______________________________________________2018 ________________________________________________
Blouet, A., Rousselet, M.-C., Le Bris, Y., Ribourtout, B., Bouvier, A., Cottin, L., Jouanneau-Courville, R., Blanchet, O., Ugo, V., Luque Paz, D., 2018. Imatinib Treatment of Chronic Myeloid Leukemia Reveals a Preexisting CALR-mutated Essential Thrombocythemia: HemaSphere 2, e29. https://doi.org/10.1097/HS9.0000000000000029
Bouvier, A., Ribourtout, B., François, S., Orvain, C., Luque Paz, D., Beucher, A., Guérard, A., Guardiola, P., Ugo, V., Blanchet, O., Geneviève, F., Schmidt, A., Hunault-Berger, M., 2018. Donor cell-derived acute promyelocytic leukemia after allogeneic hematopoietic stem cell transplantation. Eur J Haematol 101, 570–574. https://doi.org/10.1111/ejh.13143
Dumas, P.-Y., Mansier, O., Prouzet-Mauleon, V., Koya, J., Villacreces, A., Brunet de la Grange, P., Luque Paz, D., Bidet, A., Pasquet, J.-M., Praloran, V., Salin, F., Kurokawa, M., Mahon, F.-X., Cardinaud, B., Lippert, E., 2018. MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms. BMC Cancer 18, 1098. https://doi.org/10.1186/s12885-018-4993-2
Garban, F., Guyard, A., Labussière, H., Bulabois, C.-E., Marchand, T., Mounier, C., Caillot, D., Bay, J.-O., Coiteux, V., Schmidt-Tanguy, A., Le Niger, C., Robin, C., Ladaique, P., Lapusan, S., Deconinck, E., Rolland, C., Foote, A.M., François, A., Jacquot, C., Tardivel, R., Tiberghien, P., Bosson, J.-L., Evaluation of the Efficacy of Platelets Treated With Pathogen Reduction Process (EFFIPAP) Study Group, 2018. Comparison of the Hemostatic Efficacy of Pathogen-Reduced Platelets vs Untreated Platelets in Patients With Thrombocytopenia and Malignant Hematologic Diseases: A Randomized Clinical Trial. JAMA Oncol 4, 468–475. https://doi.org/10.1001/jamaoncol.2017.5123
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Luque Paz, D., Boyer, F., Beucher, A., Bouvier, A., Jouanneau-Courville, R., Guardiola, P., Lambert, D., Delneste, Y., Hunault, M., Blanchet, O., Ugo, V., 2018. Concomitant CALR and LNK mutations leading to essential thrombocythemia with erythrocytosis. Blood Cells Mol Dis 71, 75–76. https://doi.org/10.1016/j.bcmd.2018.04.002
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Alloin, A.-L., Leverger, G., Dalle, J.-H., Galambrun, C., Bertrand, Y., Baruchel, A., Auvrignon, A., Gandemer, V., Ragu, C., Loundou, A., Bilhou-Nabera, C., Lafage-Pochitaloff, M., Dastugue, N., Nelken, B., Jubert, C., Rialland, F., Plat, G., Pochon, C., Vannier, J.-P., Rohrlich, P.-S., Kanold, J., Lutz, P., Sirvent, A., Oudin, C., Cuccuini, W., Michel, G., on behalf of the ELAM study group, 2017. Cytogenetics and outcome of allogeneic transplantation in first remission of acute myeloid leukemia: the French pediatric experience. Bone Marrow Transplant 52, 516–521. https://doi.org/10.1038/bmt.2016.293
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Chauveau, A., Nibourel, O., Tondeur, S., Luque Paz, D., Mansier, O., Paul, F., Wemeau, M., Preudhomme, C., Lippert, E., Ugo, V., 2017. Absence of CALR mutations in JAK2 -negative polycythemia. Haematologica 102, e15–e16. https://doi.org/10.3324/haematol.2016.154799
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Chretien, A.-S., Devillier, R., Fauriat, C., Orlanducci, F., Harbi, S., Le Roy, A., Rey, J., Bouvier Borg, G., Gautherot, E., Hamel, J.-F., Ifrah, N., Lacombe, C., Cornillet-Lefebvre, P., Delaunay, J., Toubert, A., Arnoulet, C., Vey, N., Blaise, D., Olive, D., 2017a. NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML. Oncoimmunology 6, e1307491. https://doi.org/10.1080/2162402X.2017.1307491
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Luque Paz, D., Ianotto, J.-C., Chauveau, A., Guibourg, B., Lecucq, L., Lippert, E., Ugo, V., 2016. Expansion of a BCR-ABL clone in a JAK2 V617F myeloproliferative neoplasm treated by ruxolitinib. Ann Hematol 95, 349–350. https://doi.org/10.1007/s00277-015-2518-5
Mahé, K., Luque Paz, D., Couturier, M.-A., Chauveau, A., Quintin-Roué, I., Berthou, C., Ugo, V., Lippert, E., Ianotto, J.-C., 2016. Extinction of myeloproliferative neoplasm by acquisition of a lymphoid disease: JAK2 V617F and JAK2 exon 12 allele burden disappearance during the follow-up of two patients. Ann Hematol 95, 529–531. https://doi.org/10.1007/s00277-015-2559-9
Malard, F., Labopin, M., Chevallier, P., Guillaume, T., Duquesne, A., Rialland, F., Derenne, S., Peterlin, P., Leauté, A.-G., Brissot, E., Gregoire, M., Moreau, P., Saas, P., Gaugler, B., Mohty, M., 2016. Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival. Blood 127, 1828–1835. https://doi.org/10.1182/blood-2015-12-688739
Maury, S., Chevret, S., Thomas, X., Heim, D., Leguay, T., Huguet, F., Chevallier, P., Hunault, M., Boissel, N., Escoffre-Barbe, M., Hess, U., Vey, N., Pignon, J.-M., Braun, T., Marolleau, J.-P., Cahn, J.-Y., Chalandon, Y., Lhéritier, V., Beldjord, K., Béné, M.C., Ifrah, N., Dombret, H., for GRAALL, 2016. Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia. N Engl J Med 375, 1044–1053. https://doi.org/10.1056/NEJMoa1605085
Michel, G., Galambrun, C., Sirvent, A., Pochon, C., Bruno, B., Jubert, C., Loundou, A., Yakoub-Agha, I., Milpied, N., Lutz, P., Marie-Cardine, A., Gandemer, V., Blaise, D., Michallet, M., Rialland, F., Renard, C., Oudin, C., Esmiol, S., Seux, M., Baumstarck, K., Mohty, M., Rocha, V., Dalle, J.-H., 2016. Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome. Blood 127, 3450–3457. https://doi.org/10.1182/blood-2016-01-694349
Nelken, B., Cave, H., Leverger, G., Galambrun, C., Plat, G., Schmitt, C., Thomas, C., Vérité, C., Brethon, B., Gandemer, V., Bertrand, Y., Baruchel, A., Rohrlich, P., 2016. A Phase I Study of Clofarabine With Multiagent Chemotherapy in Childhood High Risk Relapse of Acute Lymphoblastic Leukemia (VANDEVOL Study of the French SFCE Acute Leukemia Committee). Pediatr Blood Cancer 63, 270–275. https://doi.org/10.1002/pbc.25751
Orvain, C., Luque Paz, D., Dobo, I., Cottin, L., Le Calvez, G., Chauveau, A., Mercier, M., Farhi, J., Boyer, F., Ianotto, J.C., Guibourg, B., Rousselet, M.C., Zandecki, M., Ifrah, N., Hunault-Berger, M., Ugo, V., Genevieve, F., 2016. Circulating Cd34+ cell count differentiates primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms: a pragmatic study. Ann Hematol 95, 1819–1823. https://doi.org/10.1007/s00277-016-2784-x
Ravinet, A., Cabrespine, A., Socié, G., Milpied, N., Yakoub Agha, I., Nguyen, S., Michallet, M., Menard, A.L., Maillard, N., Mohty, M., Suarez, F., Huynh, A., Marchand, T., Deteix, C., Cassuto, J.P., Maury, S., Chevallier, P., Reman, O., Peffault de Latour, R., Bay, J.O., 2016. Impact of Thymoglobulin by Stem Cell Source (Peripheral Blood Stem Cell or Bone Marrow) After Myeloablative Stem Cell Transplantation From HLA 10/10-Matched Unrelated Donors: A Report From the Société Française de Greffe de Moelle et de Thérapie Cellulaire. Transplantation 100, 1732–1739. https://doi.org/10.1097/TP.0000000000000976
Rousselot, P., Coudé, M.M., Gokbuget, N., Gambacorti Passerini, C., Hayette, S., Cayuela, J.-M., Huguet, F., Leguay, T., Chevallier, P., Salanoubat, C., Bonmati, C., Alexis, M., Hunault, M., Glaisner, S., Agape, P., Berthou, C., Jourdan, E., Fernandes, J., Sutton, L., Banos, A., Reman, O., Lioure, B., Thomas, X., Ifrah, N., Lafage-Pochitaloff, M., Bornand, A., Morisset, L., Robin, V., Pfeifer, H., Delannoy, A., Ribera, J., Bassan, R., Delord, M., Hoelzer, D., Dombret, H., Ottmann, O.G., 2016. Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome–positive ALL. Blood 128, 774–782. https://doi.org/10.1182/blood-2016-02-700153
Visentin, S., Auquier, P., Bertrand, Y., Baruchel, A., Tabone, M.-D., Pochon, C., Jubert, C., Poirée, M., Gandemer, V., Sirvent, A., Bonneau, J., Paillard, C., Freycon, C., Kanold, J., Villes, V., Berbis, J., Oudin, C., Galambrun, C., Pellier, I., Plat, G., Chambost, H., Leverger, G., Dalle, J.-H., Michel, G., 2016. The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucémie de l’Enfant et de L’Adolescent Study. Biol Blood Marrow Transplant 22, 2003–2010. https://doi.org/10.1016/j.bbmt.2016.08.004
_______________________________________________2015 ________________________________________________
Boissel, N., Renneville, A., Leguay, T., Lefebvre, P.C., Recher, C., Lecerf, T., Delabesse, E., Berthon, C., Blanchet, O., Prebet, T., Pautas, C., Chevallier, P., Leprêtre, S., Girault, S., Bonmati, C., Guièze, R., Himberlin, C., Randriamalala, E., Preudhomme, C., Jourdan, E., Dombret, H., Ifrah, N., 2015. Dasatinib in high-risk core binding factor acute myeloid leukemia in first complete remission: a French Acute Myeloid Leukemia Intergroup trial. Haematologica 100, 780–785. https://doi.org/10.3324/haematol.2014.114884
Cabagnols, X., Defour, J.P., Ugo, V., Ianotto, J.C., Mossuz, P., Mondet, J., Girodon, F., Alexandre, J.H., Mansier, O., Viallard, J.F., Lippert, E., Murati, A., Mozziconacci, M.J., Saussoy, P., Vekemans, M.C., Knoops, L., Pasquier, F., Ribrag, V., Solary, E., Plo, I., Constantinescu, S.N., Casadevall, N., Vainchenker, W., Marzac, C., Bluteau, O., 2015. Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution. Leukemia 29, 249–252. https://doi.org/10.1038/leu.2014.270
Chalandon, Y., Thomas, X., Hayette, S., Cayuela, J.-M., Abbal, C., Huguet, F., Raffoux, E., Leguay, T., Rousselot, P., Lepretre, S., Escoffre-Barbe, M., Maury, S., Berthon, C., Tavernier, E., Lambert, J.-F., Lafage-Pochitaloff, M., Lhéritier, V., Chevret, S., Ifrah, N., Dombret, H., 2015. Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia. Blood 125, 3711–3719. https://doi.org/10.1182/blood-2015-02-627935
Chevallier, P., Eugene, T., Robillard, N., Isnard, F., Nicolini, F., Escoffre-Barbe, M., Huguet, F., Hunault, M., Marcais, A., Gaschet, J., Cherel, M., Guillaume, T., Delaunay, J., Peterlin, P., Eveillard, M., Thomas, X., Ifrah, N., Lapusan, S., Bodet-Milin, C., Barbet, J., Faivre-Chauvet, A., Ferrer, L., Bene, M.C., Le Houerou, C., Goldenberg, D.M., Wegener, W.A., Kraeber-Bodéré, F., 2015a. (90)Y-labelled anti-CD22 epratuzumab tetraxetan in adults with refractory or relapsed CD22-positive B-cell acute lymphoblastic leukaemia: a phase 1 dose-escalation study. Lancet Haematol 2, e108-117. https://doi.org/10.1016/S2352-3026(15)00020-4
Chevallier, P., Labopin, M., Socie, G., Rubio, M.-T., Blaise, D., Vigouroux, S., Huynh, A., Michallet, M., Bay, J.-O., Maury, S., Yakoub-Agha, I., Fegueux, N., Deconinck, E., Contentin, N., Maillard, N., Bulabois, C.-E., Francois, S., Oumedaly, R., Raus, N., Mohty, M., 2015b. Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC. Eur J Haematol 94, 449–455. https://doi.org/10.1111/ejh.12451
Chien, W.W., Catallo, R., Chebel, A., Baranger, L., Thomas, X., Béné, M.-C., Gerland, L.M., Schmidt, A., Beldjord, K., Klein, N., Escoffre-Barbe, M., Leguay, T., Huguet, F., Larosa, F., Hayette, S., Plesa, A., Ifrah, N., Dombret, H., Salles, G., Chassevent, A., Ffrench, M., 2015. The p16(INK4A)/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome. Leuk Res 39, 453–461. https://doi.org/10.1016/j.leukres.2015.01.008
Couturier, M.-A., Huguet, F., Chevallier, P., Suarez, F., Thomas, X., Escoffre-Barbe, M., Cacheux, V., Pignon, J.-M., Bonmati, C., Sanhes, L., Bories, P., Daguindau, E., Dorvaux, V., Reman, O., Frayfer, J., Orvain, C., Lhéritier, V., Ifrah, N., Dombret, H., Hunault-Berger, M., Tanguy-Schmidt, A., 2015. Cerebral venous thrombosis in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma during induction chemotherapy with l -asparaginase: The GRAALL experience: Incidence, Risk Factors, and Management of CNS Thrombosis. Am. J. Hematol. 90, 986–991. https://doi.org/10.1002/ajh.24130
Dhédin, N., Huynh, A., Maury, S., Tabrizi, R., Beldjord, K., Asnafi, V., Thomas, X., Chevallier, P., Nguyen, S., Coiteux, V., Bourhis, J.-H., Hichri, Y., Escoffre-Barbe, M., Reman, O., Graux, C., Chalandon, Y., Blaise, D., Schanz, U., Lhéritier, V., Cahn, J.-Y., Dombret, H., Ifrah, N., 2015. Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia. Blood 125, 2486–2496. https://doi.org/10.1182/blood-2014-09-599894
Fossat, C., Roussel, M., Arnoux, I., Asnafi, V., Brouzes, C., Garnache-Ottou, F., Jacob, M.C., Kuhlein, E., Macintyre-Davi, E., Plesa, A., Robillard, N., Tkaczuk, J., Ifrah, N., Dombret, H., Béné, M.C., Baruchel, A., Garand, R., for the French Multicenter Study Groups for Pediatric and Adult ALL, 2014. Methodological aspects of minimal residual disease assessment by flow cytometry in acute lymphoblastic leukemia: A French multicenter study: Cytometry. Part B, Clinical Cytometry 88, 21-29. https://doi.org/10.1002/cytob.21195
Huet, S., Dulucq, S., Chauveau, A., Ménard, A., Chomel, J.-C., Maisonneuve, H., Legros, L., Perrin, M.-C., Ferrant, E., Moreilhon, C., Couturier, M.-A., Sujobert, P., Magaud, J.-P., Ugo, V., Chabane, K., Raynaud, S., Hayette, S., GBMHM (Groupe des Biologistes Moléculaires des Hémopathies Malignes, French Molecular Biology Group in Hematology), 2015. Molecular characterization and follow-up of five CML patients with new BCR-ABL1 fusion transcripts: Characterization of five new BCR-ABL1 transcripts. Genes Chromosomes Cancer 54, 595–605. https://doi.org/10.1002/gcc.22263
Hunault-Berger, M., Leguay, T., Huguet, F., Leprêtre, S., Deconinck, E., Ojeda-Uribe, M., Bonmati, C., Escoffre-Barbe, M., Bories, P., Himberlin, C., Chevallier, P., Rousselot, P., Reman, O., Boulland, M.-L., Lissandre, S., Turlure, P., Bouscary, D., Sanhes, L., Legrand, O., Lafage-Pochitaloff, M., Béné, M.C., Liens, D., Godfrin, Y., Ifrah, N., Dombret, H., Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), 2015. A Phase 2 study of L-asparaginase encapsulated in erythrocytes in elderly patients with Philadelphia chromosome negative acute lymphoblastic leukemia: The GRASPALL/GRAALL-SA2-2008 study: L-asparaginase within erythrocytes in elderly ALL patients. Am. J. Hematol. 90, 811–818. https://doi.org/10.1002/ajh.24093
Itzykson, R., Thépot, S., Berthon, C., Delaunay, J., Bouscary, D., Cluzeau, T., Turlure, P., Prébet, T., Dartigeas, C., Marolleau, J.-P., Recher, C., Plantier, I., Stamatoullas, A., Devidas, A., Taksin, A.-L., Guièze, R., Caillot, D., Vey, N., Adès, L., Ifrah, N., Dombret, H., Fenaux, P., Gardin, C., 2015. Azacitidine for the treatment of relapsed and refractory AML in older patients. Leuk Res 39, 124–130. https://doi.org/10.1016/j.leukres.2014.11.009
Verger, E., Cassinat, B., Chauveau, A., Dosquet, C., Giraudier, S., Schlageter, M.-H., Ianotto, J.-C., Yassin, M.A., Al-Dewik, N., Carillo, S., Legouffe, E., Ugo, V., Chomienne, C., Kiladjian, J.-J., 2015. Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations. Blood 126, 2585–2591. https://doi.org/10.1182/blood-2015-07-659060